72-Hole Tournament
- 14 strokes - Cindy Mackey, 1986 MasterCard International Pro-Am
54-Hole Tournament
- 11 strokes - Jan Stephenson (1981 Mayflower Classic) and Annika Sorenstam (2002 Kellogg-Keebler Classic)
Note: Louise Suggs won the 1949 U.S. Women's Open by 14 strokes. That was prior to the founding of the LPGA, but the LPGA does retroactively recognize the win as an LPGA Tour victory. However, the tour does not list Suggs' 14-stroke margin of victory among its official records.
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