Players rotate being the "Wolf." The player designated as the "Wolf" gets to choose whether to play the hole 1 against 3 (himself against the other three players in the group) or 2 on 2.
And if the Wolf chooses to play 2 on 2, he must choose his partner immediately following that player's drive. Example: Player A is the Wolf. Player B hits a bad drive. Player C hits a pretty good drive. If the Wolf wants C as a partner, he must claim his partner before Player D hits his tee ball.
The side with the lowest better ball score wins the hole. If it's 2 on 2, then the winning side wins the bet. If it's 1 on 3, the Wolf wins double or loses double.
There's also Lone Wolf, in which the Wolf announces before anyone tees off - including himself - that he's going it alone, 1 on 3. On a Lone Wolf hole, the Wolf wins triple or loses triple.
For more details on Wolf, read this explanation of Wolf in Chi Chi Rodriguez's book, "Golf Games You Gotta Play."

